对称四甲基取代六元瓜环对醋酸地塞米松的增溶作用

Solubility Improvement of Dexamethasone Acetate by Tetramethyl Substituted Cucurbit[6] uril

利用微孔滤膜分离方法研究了对称四甲基取代六元瓜环(TMeQ[6])对醋酸地塞米松的增溶作用,并利用差热分析法(DTA)分析TMeQ[6]和醋酸地塞米松的包结物。结果表明,TMeQ[6]对醋酸地塞米松有一定的增溶作用,随TMeQ[6]浓度增大,醋酸地塞米松的溶解度呈增大趋势,当TMeQ[6]浓度从0.04mmol/L提高至0.28mmol/L增溶倍数可达4～17倍;当温度从10℃升至70℃,增溶倍数先下降然后趋于稳定。同时,还利用共溶剂法制备了TMeQ[6]与醋酸地塞米松的固体包结物,并对其主客体作用进行了DTA研究。

The solubility improvement of dexamethasone acetate by tetramethyl substituted cucurbit[6]urils（TMeQ[6]） was studied with the micro porous filter membrane separation technique,and the solid inclusion complex of TMeQ[6] and dexamethasone acetate was analyzed with the method of DTA.The results show that TMeQ[6] was able to increase the solubility of dexamethasone acetate,and the solubilization improvement could reach 4~17-fold when the concentration of TMeQ[6] increased from 0.04 to 0.28 mmol/L.While the temperature increased from 10 ℃ to 70 ℃,the solubilization decreased in the range of 10~30 ℃,and then leveled off in the range of 40~70 ℃.At the same time,the solid inclusion complex of dexamethasone acetate with TMeQ[6] was prepared through cosolvent method,and its host-guest interaction was studied by DTA.