摘要
目的建立乙基纤维素中残留有机溶剂二氯甲烷的测定方法。方法采用顶空进样毛细管气相色谱法,FID检测器,色谱柱为DB-624石英毛细管柱(30m×0.3mm,1.8μm),载气为氮气,柱温90℃。结果二氯甲烷可得到有效分离,在所考察的质量浓度范围内线性关系良好,r=0.9996(n=6),平均回收率为98.99%,RSD=1.04%(n=9)。结论所用方法灵敏、准确、快速,可作为乙基纤维素中残留有机溶剂二氯甲烷的检测方法 。
Objective To establish a headspace capillary gas chromatography method for determining the residual organic solvent methylene chloride in ethyl cellulose. Methods Methylene chloride was separated on the DB-624 capillary column（30 m ×0. 3 mm, 1.8μm）,the column temperature was 90 ℃. Results Methylene chloride was separated with the good linearity, r = 0. 999 6（ n = 6）. The average recovery rate was 98.99%, RSD=1. 04% （n=9）. Conclusion The methods is proved to be accurate and sensitive after validation, which can be uses for determining the residual organic solvent methylene chloride in ethyl cellulose.
出处
《中国药业》
CAS
2010年第8期48-49,共2页
China Pharmaceuticals
关键词
顶空气相色谱法
乙基纤维素
残留有机溶剂
headspace capillary gas chromatography
ethyl cellulose
residual organic solvent
