急性脑梗死患者血清sVAP-1的水平变化及临床意义

Clinical significance of serum soluble vascular adhesion protein-1 levels in acute cerebral infarction

目的观察急性脑梗死患者血清可溶性血管黏附蛋白-1(sVAP-1)的水平,探讨sVAP-1与急性脑梗死的关系及临床意义。方法随机选择急性脑梗死患者40例作为病例组,30例健康人为对照组,分别测定外周血清sVAP-1的水平。结果急性脑梗死组sVAP-1明显高于健康对照组(P<0.05),且在脑梗死神经功能缺损程度重度组血清sVAP-1水平明显高于轻度组及中度组,差异有统计学意义(P<0.05)。结论急性脑梗死患者血清sVAP-1水平升高,其水平增高可能会进一步加重脑梗死的发生与发展。

Aim To observe serum soluble vascular adhesion protein-1（sVAP-1） levels of patients in acute cerebral infarction,to explore the sVAP-1 with acute cerebral infarction and its clinical significance.Methods 40 patients with acute cerebral infarction were randomly selected case group,30 healthy human as control group,and peripheral blood clearance sVAP-1 levels were measured.Results in acute cerebral infarction group sVAP-1 was significantly higher than the control group（P0.05）,and the extent of neurological deficits in cerebral infarction and severe serum sVAP-1 levels were significantly higher than the mild and moderate.The differences were statistically significant.Conclusion Patients of acute cerebral infarction have elevated levels of sVAP-1,whose increased levels may further increase the occurrence and development of cerebral infarction.