p38 MAPK信号传导通路及其抑制剂的研究现状

p38 mitogen activated protein kinase pathway and its inhibitor

丝裂原活化蛋白激酶(mitogen-activated protein kinases,MAPKs)级联反应是细胞内重要的信号传导系统之一,p38 MAPK信号传导通路是MAPK通路的分支之一,它通过转录因子磷酸化而改变基因的表达水平,参与多种胞内信息传递过程,能对广泛的细胞外刺激发生反应,介导细胞生长、发育、分化及死亡全过程。近年研究发现,p38 MAPK在许多疾病的发病过程中具有重要作用,其抑制剂也在相关疾病的动物模型和临床试验中获得令人可喜的成果。

The cascade reaction of mitogen-activated protein kinases（MAPKs） is one of the vital intracellular signal transduction systems,p38 being a member of MAPKs.It can change the level of gene expression through phosphorylation of transcription factor and is involved in intracellular information transfer.It can respond to wide extracellular stimulus and mediate growth,development,differentiation and death of cells.The recent researches indicate that p38 MAPK plays a majoy role in the development of many diseases and its inhibitor achieves encouraging results in animal model of related diseases and clinical trial.