双相情感障碍患者及其一级亲属的三维人格特征研究

The three-dimensional personnality of patients with bipolar affective disorder and their first-degree relatives

目的探讨双相情感障碍患者及其一级亲属的三维人格特征。方法采用三维人格问卷(TPQ)对78例缓解期双相情感障碍患者(患者组)、53名双相情感障碍患者的一级亲属(新属组)及97名正常对照个体(对照组)进行三维人格特征的评定。结果患者组寻求新奇维度(NS)和伤害回避维度(HA)分数高于对照组(P<0.05),亲属组NS分数高于对照组(P<0.05);患者组和亲属组的NS1、NS2、HA1因子分均高于对照组(P<0.05或P<0.01)。结论冲动、寻求刺激、悲观是反映双相情感障碍遗传易感性的人格特征,NS维度可考虑作为双相情感障碍的遗传"内表型"标志。

Objective To explore the three-dimensional personality trait in patients with bipolar affeetiVe disorder and their first-degree relatives. Methods Seventy-eight patients with bipolar affective disorder, 53 first-degree relatives of the patients and 97 normal controls were investigated by Three-dimensional Personality Questionnaire I TPQ）. Results The scores of NS dimension and HA dimension in patient group were higher than those in control group （ P 〈 0. 05 ）. The NS dimension scores in relative group were higher than those in control group （ P 〈 0. 05 ）. The scores of NS1, NS2 and HA1 factor in patient group and relative group were higher than those in control group （ P 〈 0.05 or P 〈 0. 01 ）. Conclusion Impulse, excitement seeking and pessimistic personality traits reflect the genetic susceptibility of bipolar affective disorder. NS dimension could be considered as the genetic endophenotype sign of bipolar affective disorder.