老年非小细胞肺癌患者术后生存期的研究

Survival analysis of elderly patients with NSCLC after surgery

目的探讨影响70岁以上非小细胞肺癌患者术后生存期的相关因素,为高龄肺癌患者的手术方式选择提供参考。方法回顾性分析手术治疗的70岁以上高龄非小细胞肺癌患者95例,利用Kaplan-Merier单因素和COX回归分析性别、年龄、症状、伴随疾病、并发症、手术方式、病理分期、体力状况(ECOG)评分、病理类型等9个因素对术后生存期的影响。结果术后随访截止2009年6月,随访率90.53%(失随访9例),术后总的1、3、5年生存率分别为73.5%、63.6%、43.1%,COX回归多因素分析显示,影响术后生存的独立因素为:病理分期和ECOG评分。结论70岁以上非小细胞肺癌患者,病理分期早和术后体力状态好的患者术后生存期长。

Objective To explore the prognostic factors that affecting survival of NSCLC in 70 years of age or older after surgery,which can provide reference for resection in them.Methods We retrospectively analyzed NSCLC patients aged more than 70 years who underwent lung cancer resection.All the potential prognostic factors,including gender,age,symptoms,comorbidities,complications,operation modes,pathologic stage,ECOG performance status（Zabrod scale of Eastern Cooperative Oncology Group）and pathology types were analyzed by COX regression in SPSS 13.0.Results The postoperative follow-up terminated by June 2009,with 9 cases lost.1,3,5-year survival rate were 73.5%、63.6%、43.1% respectively.COX regression showed pathologic stage and ECOG performance status were the independent prognostic factors.Conclusion Elderly patients with NSCLC in early stage and good performance status tend to have longer life expectance after surgery.