肝肾阴虚证与血管内皮功能障碍的相关性研究

Relationship between Liver-kidney Rin Deficiency and Vascular Endothelial Dysfunction

目的:探讨肝肾阴虚证与内皮细胞功能障碍(endothelial dysfunction,ED)的相关性。方法:根据中医辨证分型选取肝肾阴虚患者60例,非肝肾阴虚患者60例,健康对照组30例。分别检测患者血浆内皮素(ET)、一氧化氮(NO)、超敏C反应蛋白(hs-CRP)和超氧化物歧化酶(SOD)活性,并分析与肝肾阴虚证间的关系。结果:肝肾阴虚组、非肝肾阴虚组与正常人组比较,ET、hs-CRP水平均明显增高,有显著性差异(P<0.01),NO、SOD水平明显降低,有显著性差异(P<0.01)。肝肾阴虚组与非肝肾阴虚组比较,ET水平明显增高,有显著性差异(P<0.01);SOD水平明显降低,有显著性差异(P<0.05);NO水平明显降低,有显著性差异(P<0.01);hs-CRP水平无显著性差异。肝肾阴虚组患者证候量化评分与ET水平呈明显正相关(r=0.890,P<0.01),与NO、SOD水平呈明显负相关(r=-0.885、-0.708,P<0.01),与hs-CRP水平无明显相关性(P>0.05)。结论:血管内皮功能损伤可能是肝肾阴虚证的病理生理基础。

Objective：To investigate the relationship between liver-kidney yin deficiency and vascular endothelial dysfunction. Method Selecting 60 cases of liver-kidney yin deficiency and 60 cases of non liver-kidney yin deficiency according to Syndrome Differentiation of TCM,and selecting 30 cases of the normal group. The concentration of plasma ET,NO,hs-CRP and SOD was tested respectively,the relationship between the above indexes and liver-kidney yin deficiency was analyzed. Results Compared with the normal group,the concentration of plasma ET,and hs-CRP were significantly increased （P 0. 01） in the groups of liver-kidney yin deficiency and non liver-kidney yin deficiency. Compared with the normal group,the concentration of plasma NO and SOD were significantly decreased （P 0. 01） in the groups of liver-kidney yin deficiency and non liver-kidney yin deficiency. Compared with non liver-kidney yin deficiency group,the concentration of plasma ET were significantly increased （P 0. 01）,the concentration of plasma SOD were significantly decreased （P 0. 05）,the concentration of plasma NO were significantly decreased （P 0. 01） in the group of liver-kidney yin deficiency. In the groups of liver-kidney yin deficiency,there was a positive correlation between the TCM syndrome evaluation and the concentration of plasma ET（r = 0. 890,P 0. 01）,and a negative correlation between the TCM syndrome evaluation and the concentration of plasma NO and SOD（r =-0. 885、-0. 708, P 0. 01）,no obvious correlation was found between the TCM syndrome evaluation and the concentration of plasma hsCRP. Conclusion The vascular endothelial dysfunction was possibly the pathophysiological basis of liver-kidney yin deficiency.