激活素A与原发性高血压的相关性研究

Association between Activin A and essential hypertension

目的:通过对高血压患者血清激活素A(ACTA)表达水平的检测,来探讨其与高血压病的发生发展的相关性。方法:选择单纯高血压病患者31例、高血压病合并冠心病患者33例为实验组,健康者20例为对照组。用酶联免疫吸附测试法对各组血清ACTA的浓度进行测定,同时检测血生化指标。数据采用SPSS13.0软件进行统计学比对分析。结果:单纯高血压病组血清ACTA含量高于正常对照组(P<0.05),高血压病合并冠心病组高于单纯高血压病组差异有统计学意义(P<0.01)。并且血清ACTA水平与血压水平呈正相关。结论:ACTA表达水平与血压水平呈正相关,提示其可能参与了高血压病的发生发展。作用方式可能与血管壁的炎症反应有关。

Objective：To observe the level of plasma Aetivin A （AetA） and investigate the relationship between plasma ActA and the development of essential hypertension. Methods：We selected 31 cases of simple essential hypertension and 33 cases of essential hypertension with coronary artery disease as experiment group and 20 healthy individuals as control group. The serum ActA level of each group was detected by enzyme--linked immunosorbent assay and the plasma biochemistry index was measured. The statistical software SPSS13. 0 was used for data. Results： The plasma ActA level in the simple essential hypertension group was higher than that of the control group （P 〈 0.05）, and the plasma ActA level of the essential hypertension with coronary artery disease group was higher than that of the simple essential hypertension group （P 〈 0. 01）. There was a positive correlation between plasma ActA and blood pressure. Conclusion：The positive correlation between plasma ActA and blood pressure suggests that the ActA may be involved in the occurrence and development of essential hypertension, and its mode of action may be related to the inflammatory reaction of the blood vessel wall.