广州市献血者抗肠道病毒EV71中和抗体滴度流行病学调查

Seroepidemiology investigation of EV71 neutralizing activity in healthy blood donors in Guangzhou

目的对广州地区100名健康献血者抗肠道病毒EV71中和抗体滴度分布进行调查。方法从广州血液中心收集健康成人血浆100份,按年龄≤24岁、24—27岁、28—34岁和≥35岁分成4组,用中和试验测定血浆中EV71中和抗体,并对检测结果进行统计学分析。结果100名健康献血者中EV71血浆阳性率为65%,血浆阳性率与年龄相关,≥35岁年龄组的阳性血浆率为37.5%,中和抗体几何平均滴度为3.225,明显低于其他各年龄组。结论19—34岁人群的血浆更适合EV71感染的补充治疗。

Objective To investigate Human Enterovirus EV71 neutralizing antibody levels and distribution in healthy blood donors in Guangzhou.Methods A total of 100 sera specimens were colleted from Guangzhou Blood Center.The specimens were divided into 4 groups according to the age of the donors,and were tested for EV71 neutralizing antibody levels by using neutralization test.Results About 65% of the samples had anti-EV71 neutralizing activities.The positive rates correlated with the age of the donors.The positive rate for the age group of ≥35 years old was 37.5% and the GMT was 3.225.These numbers are significantly lower than other age groups.Conclusion Plasma from 19—34 year old donors is more appropriate for the complementary therapy of EV71 infection.