持续正压通气对重度支气管哮喘患儿肺功能的影响

Effect of nasal continious positive active pressure on lung function in children with severe asthma

【目的】观察持续正压通气对重度支气管哮喘患儿肺功能的影响。【方法】将重度支气管哮喘患儿168例随机分为治疗组[持续正压通气(continious positive airway pressure,CPAP)]和对照组(面罩吸氧),两组均给予常规治疗。3d后监测喘息缓解情况、哮鸣音消失时间、最大呼气峰流速(PEFR)、第1秒最大呼气率(FEV1%)、用力肺活量(FVC)、血气分析(PaO2)等指标的变化。【结果】治疗组在哮喘缓解时间、哮鸣音消失时间、PEFR、FEV1%、PaO2等方面与对照组间差异有统计学意义(P<0.05)。【结论】持续正压通气可以明显改善重度支气管哮喘患儿的症状和肺功能。

[Objective] To observe the influence that continious positive airway pressure （CPAP） imposes on the lung function of the severe bronchial asthmatic children. [Methods] Randomly divided 168 severe bronchial asthmatic children into two groups. The treatment group was given the treatment of CPAP on the base of routine treatment and the control group was given mask oxygen-inspiration. To monitor the changes of remission asthma, disappearance time of wheeze, peak expiratory flow rate（PEFR）, forced expiratory volume in first second（FEV1%）, forced vital capacity（FVC）, and blood gas analysis （PaO2） three days later. [Result] The differents of remission asthma, disappearance time of wheeze, PEFR,FEV1%, PaO2.PH between treatment group and control group were significant（P〈0.05）. [Conclusion] CPAP can obviously improve the symptoms and lung functions of severe bronchial asthmatic children.