老年高脂肪酶血症患者尿胰蛋白酶原2检测

Detection of urinary trypsinogen 2 in elderly patients with hyperlipasemia

目的探讨尿胰蛋白酶原2试纸检测对于判断高脂肪酶血症老年患者是否罹患胰腺疾病的临床意义。方法对50例高脂肪酶血症老年患者同时行血清胰酶和尿胰蛋白酶原2试纸检测和腹部影像学检查，分析其临床特征及检测的特异性和敏感性。结果在高脂肪酶血症老年患者，尿胰蛋白酶原2试纸检测阳性诊断胰腺疾病的敏感性为68．97％，特异性为80．95％，阳性预测值为83．33％，阴性预测值65．38％。高脂肪酶血症伴肾衰者近期死亡率高于肾功能正常者（P〈0．01）。结论尿胰蛋白酶原2试纸检测对于高脂肪酶血症老年患者胰腺疾病的诊断及排除诊断有一定价值。

Objective To study the value of urinary trypsinogen 2 measurement in the diagnosis of pancreatic disease in the elderly patients with hyperlipasemia. Methods Urinary trypsinogen 2, serum lipase and amylase detection as well as abdominal ultrasound and CT scan examination were performed in 50 elderly patients with hyperlipasemia, and their clinical features, the sensitivity and specificity of urinary trypsinogen2 measurement in the diagnosis of pancreatic disease were analysed. Results The sensitivity and specificity of urinary trypsinogen 2 test in the diagnosis of pancreatic disease were 68.97% and 80.95 %, respectively. The positive predict value and negative predict value of urinary trypsinogen 2 test in the diagnosis of pancreatic disease were 83.33 % and 65.38 %, respectively. The mortality of hyperlipasemia patients with renal failure was higher than those without renal failure （P〈0.01）. Conclusion Urinary trypsinogen2 test is valuable for the diagnosis of pancreatic disease in elderly patients with hyperlipasemia.