无创正压通气治疗慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭疗效探讨

The discussion on curative effect of non-invasive ventilation therapy to COPD patiens with type Ⅱ respiratory failure

目的探讨在慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭患者中使用无创通气的疗效。方法 56例COPD合并Ⅱ型呼吸衰竭的患者分为治疗组29例,采用常规治疗(药物治疗+吸氧)加用无创通气;对照组27例,采用常规治疗。观察治疗前后的临床指标和4,12,24、48h的动脉血气。结果治疗组给予无创通气后动脉血气PaO2明显上升(P<0.05),PaCO2明显下降(P<0.05)。结论慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的患者应用无创通气后可以有效改善病情,且减少气管插管行有创通气的发生率。

Objective To discuss curative effect of non-invasive ventilation therapy to COPD patients with Ⅱ respiratory failure. Methods A total of 56 COPD patients with Type Ⅱ respiratory failure were divided into 2 groups. The therapy group included 29 patients and were given routine therapy（ meditations and oxygen）and non-invasive ventilation; the contrast group included 27 patients were only given routine therapy. Observations of the clinical indicators were made before and after the treatment at 4,12,24,48 h of the arterial blood gas. Results After the non-invasive ventilation to patients in the therapy group, PaO2 was observed to increase dramatically（ P 〈 0. 05 ）, while PaCO2 decreased dramatically （ P 〈 0. 05 ）. Conclusion Chronic obstructive pulmonary disease and respiratory failure Ⅱ patients with non-invasive ventilation can effectively improve conditions and reduce intubation of the incidence of invasive ventilation.