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转录调节因子Ets-1在肺腺癌的表达及其意义 被引量：3

Expression and its significance of transcription factor Ets-1 in lung adenocarcinoma
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摘要 目的检测转录调节因子Ets-1在肺腺癌组织的表达。方法检测Ets-1在46例肺腺癌组织及16例癌旁正常组织中的表达。结果 Ets-1在肺腺癌组织中阳性表达率为71.74%,显著高于癌旁正常肺组织中的12.50%,且差异具有统计学意义(P<0.001);Ets-1的阳性表达水平与病人的性别、年龄以及TNM分期无关(P>0.05),与肺腺癌的肿瘤大小、分化程度、淋巴结转移密切相关(P<0.05)。结论检测Ets-1可能作为判定肺腺癌浸润转移的有效指标。 Objective To detect the expression of Ets-1 （ E26 transformation specific） in human lung adenocarcinoma tissues. Methods The expression of Ets-1 was detected in lung adenocarcinoma（ n = 46 ） and the normal tissues side-carcinoma（ n = 16） by immuuohistochemistry. Results The protein expression of Ets-1 in lung adenocarcinoma tissues was significantly higher than those in pericancerous tissues（ P 〈 0. 001 ）. The positive rate of Ets-1 was correlated with the tumor＇s size, pathology grading and lymph node metastasis of lung adenocarcinoma（ P 〈 0. 05 ）. Conclusion The datectoion of Ets-1 may served as a valuable factor for estimating metastasis of lung adenocarcinoma.
作者 崔秀娟 胡碧丹 刘善青 张妍蓓
机构地区 巢湖职业技术学院 安徽医科大学第一附属医院干部呼吸内科
出处 《临床肺科杂志》 2010年第6期832-833,共2页 Journal of Clinical Pulmonary Medicine
关键词 肺腺癌 ETS-1 免疫组织化学 lung adenocarcinoma Ets-1 immunohistochemistry
分类号 R734.2 [医药卫生—肿瘤]
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参考文献7

  • 1Tsutsumi S,Kuwano H,Nagashima N,et al.Ets-1 expression in gastric cancer[M].Hepatogastroenterology,2005,52:654-656.
  • 2Nakayama T,Ito M,Ohtsuru A,et al.Expression of the Ets-1 proto-oncogene in human colorectal carcinoma[J].Mod Pathol,2001,14(5):415-422.
  • 3Fujimoto J,Aoki I,Toyoki H,et al.Clinical implications of expression of ETS-1 related to angiogenesis in metastatic lesions of ovarian cancers[J].Oncology,2004,66(5):420-8.
  • 4Tohoku.Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma[J].J Exp Med,2007,213(1):41-50.
  • 5Lincoln DW 2nd,Bove K.The transcription factor Ets-1 in breast cancer[J].Front Biosci,2005,10:506-11.
  • 6Hashiya N,Jo N,Aoki M,et al.In vivo evidence of angiogenesis induced by transcription factor Ets-1:Ets-1 is located upstream of angiogenesis cascade[J].Circulation,2004,109(24):3035-41.
  • 7李珀,何常,徐恒天,钟愉.p21^(WAF1)、ETS-1、血管内皮生长因子-C蛋白在鼻咽癌组织中的表达及鼻咽癌内微淋巴管、微血管密度的临床病理意义[J].实用肿瘤杂志,2008,23(5):438-442. 被引量：5

二级参考文献11

  • 1陈德利,刘弋.血管内皮生长因子-C与肿瘤转移的研究进展[J].国外医学（肿瘤学分册）,2004,31(7):502-505. 被引量：4
  • 2石小燕,马丁.淋巴管生成与肿瘤转移研究进展[J].国外医学（肿瘤学分册）,2004,31(9):667-670. 被引量：9
  • 3Harper JW, Adami GR, Wei N, et al. The p21 cdkinteracting protein cipl is a protent inhibition of G1 cyclindependent kinases [J]. Cell, 1993,75 (4) : 805 - 816.
  • 4Xiong Y, Zhang H, Beach D, et al. Subunit rearrangement of the cycline-dependent kinases is associated with cellular transformation [J]. Genes Dev, 1993,7(8) : 1572-1583.
  • 5Lukas J,Grishen S,Saffari B,et al. WAF1/CIP1 gene polymorphism and expression in carcinoma of the breast, ovary, and endmetrium [J]. Am J Pathol, 1997,150(1),167-175.
  • 6Joukov V, Kumar V, Sorsa T, et al. A recombinant mutant vascular endothelial growth factor C that has lost endothelial growth factor receptor-2 binding, activation, and vascular permeability activities [J ]. J Biol Chem,1998,273(12) :6599-6602.
  • 7David G. New molecular markers for the study of tumor lymphangiogenesis[ J]. Anticancer Res, 2001, 21(4):27-49.
  • 8Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours [J]. Histopathology 2005,46(3) : 396-402.
  • 9Ogawa Y, Nakata B. Microvessel quantitation in invasive breast cancer by staining for factor V-elated intigen [J]. Br J Cancer, 1995,71 (6) : 1297- 1301.
  • 10曾俊,龚玲玲,陈晓,张弓,王敏.微血管密度和血管内皮生长因子、P53表达与鼻咽癌预后的关系[J].湖北医科大学学报,2000,21(3):187-189. 被引量：6

共引文献4

同被引文献25

  • 1Lo IC,Lin TM,Chou LH,et al.Ets-1 mediates platelet-derived growth factor-B induced thrombomodulin expression in human vascular smooth muscle cells[J].Cardiovasc Res,2009,8l(4):771-773.
  • 2Eo J,Han K,Murphy K,et al.Etv 5,an ETS transcription factor,is expressed in granulosa and cumulus cells and serves as a transcriptional regulator of the cyclooxygenase-2[J].J Endocrinol,2008,198(2):281-285.
  • 3Du ZJ,Kamei M,Suzuki M,et al.Coordinated expression of Ets-l,pERKl/2,and VEGF in retina of streptozotocin-induced diabetic rats[J].Ophthalmic Res,2007,39(4):224-225.
  • 4Tohoku J.Ets-1 proto-oncogene as a potential predictor for poor prognosis of lung adenocarcinoma[J].J Exp Med,2007,213(1):41-50.
  • 5Fuhrer D,Eszlinger M,Karger S,et al.Evaluation of insulin-like growth factor II,cyclooxygenase-2,ets-1 and thyroid-specific thyroglobulin mRNA expression in benign and malignant thyroid tumours[J].Eur J Endocrinol,2005,152(5):785-790.
  • 6Sahin A,Vercamer C,Kaminski A,et al.Dominant-negative inhibition of Ets-1 suppresses tumor,invasion and migration in rat C6 glioma cells and reveals differentially expressed target genes[J].Int J Oncol,2009,34 (2):377-389.
  • 7Taniguchi H,Fujiwara Y,Doki Y,et al.Gene therapy using ets-1 transcription factor decoy for peritoneal dissemination of gastric cancer[J].Int J Cancer,2007,121(7):1609-1617.
  • 8Li M,Xiao T,Zhang Y,et al.Prognostic significance of matrix met alloproteirase-1 levels in peripheral plasma and tumour tissues of lung cancer patients[J].Lung Cancer,2010,69 (3):341-347.
  • 9Magary SP,Ryan MW,Tarnuzzer RW,et al.Expression of matrix metalloproteinases and tissue inhibitor of metalloproteinases in laryngeal and pharyngeal squamous cell carcinoma:A quantitative analysis[J].Otolaryngol Head Neck Surg,2000,122(5):712-716.
  • 10Salnikow K,Aprelikova O,Ivanov S,et al.Regulation of hypoxiainducible genes by ETS1 transcription factor[J].Carcinogenesis,2008,29 (8):1493-1499.

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临床肺科杂志
2010年 第6期

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