1709株临床分离菌的药敏及耐药状况分析

Analysis of drug sensitivity and drug resistance of 1709 strains of clinically isolated pathogenic bacteria

目的:了解广西医科大学第四附属医院2008年临床分离菌对常用抗菌药物的药敏及耐药状况。方法:采用美国德灵Autoscan4自动细菌鉴定/药敏分析系统对细菌做鉴定和药敏分析。结果:2008年共分离1709株细菌,G-杆菌1391株,占81.39%,其中大肠杆菌、肺炎克雷伯菌和铜绿假单胞菌分别占38.53%、26.74%和19.05%。G+球菌318株,占18.61%,其中葡萄球菌和肠球菌分别占50.31%和49.69%。大肠杆菌产超广谱β-内酰胺酶比例达61.19%,对大多数被测药物耐药率>50%;G-杆菌对亚胺培南的耐药率<10%;耐苯唑西林金黄色葡萄球菌占葡萄球菌的33.59%,对万古霉素耐药率为0%。结论:细菌谱及药敏监测资料对临床合理选用抗菌药有参考价值。

Objective：To investigate drug sensitivity and drug resistance of the clinically isolated bacteria to the routine antibacterials in the Fourth Affiliated Hospital of Guangxi Medical University.Methods：Identification and analysis of drug sensitivity of bacteria were implemented with American Autoscan4 automatic bacteria identification and drug sensitivity analytical system.Results：A total of 1709 strains of pathogenic bacteria were isolated in 2008.Gram negative bacteria were 1391 strains（81.39%）,including Escherichia coli（38.53%）,Klebsiella pneumoniae（26.74%） and Pseudomonas aeruginosa（19.05%）,respectively.Gram positive coccis were 318 strains（18.61%）,including Staphylococci（50.31%） and Enterococci（49.69%）,respectively.The percentage of Escherichia coli producing extended spectrum β-lactamases（ESBLs） was 61.19%,and more than 50% of them showed drug resistance to most of the tested antibacterials.The drug resistance rate of G-bacilli to imipenem was less than 10%.Oxacillin-resistant Staphylococcis aureus（ORSA） accounted for 33.59% of Staphylococci,while 0% resistance rate to vancomycin.Conclusion：It is valuable to monitor the bacterial spectrum and drug resistance for rational use of antibacterials.