利奈唑胺等抗菌药物对肠球菌属体外抗菌活性评价

Antimicrobial activity of linezolid and other antimicrobial agents against Enterococci spp. in vitro

目的了解利奈唑胺等抗菌药物对某院临床分离的肠球菌属细菌的体外抗菌活性。方法采用美国德灵Microscan WalkAway-40全自动微生物分析仪对临床标本分离培养的肠球菌属细菌进行鉴定及药物敏感试验。结果 117株肠球菌属细菌中未检出对利奈唑胺耐药的菌株;屎肠球菌和粪肠球菌对万古霉素的耐药率分别为4.41%和5.71%,对青霉素、氨苄西林、红霉素、高浓度庆大霉素、左氧氟沙星、环丙沙星等药物的耐药率达70%以上。结论利奈唑胺对肠球菌属细菌具有良好的抗菌效果,尤其对多重耐药株所致感染的控制将具有重要作用。

Objective To evaluate in vitro activity of linezolid and other antimicrobial agents against Enterococci spp. isolated from clinic. Methods Identification and antimicrobial sensitivity test of Enterococci spp. was carried out by Microscan WalkAway-40 system. Results No linezolid-resistant strain was detected in 117 Enterococci spp. strains. Resistant rate of Enterococcus faecium and Enterococcus faecalis against vancomycin was 4. 41 % and 5.71% respectively, the resistant rates to penicillin, ampicillin, erythromycin, high concentration gentamycin, levofloxacin and ciprofloxacin were all above 70%. Conclusion Linezolid has high activity against Enterococci spp. , especially the control of infections caused by multidrug-resistant isolates.