鲍曼不动杆菌肺部感染的临床特点及耐药性分析

Clinical characteristics and drug resistance of Acinetobacter baumannii pulmonary infection

目的分析和总结鲍曼不动杆菌肺部感染的临床特点及耐药规律。方法对2006年6月-2008年6月间住院的65例鲍曼不动杆菌肺部感染患者临床资料进行分析。结果鲍曼不动杆菌肺部感染在综合重症监护病房(ICU,41.54%)、神经内科监护病房(29.23%)、神经外科监护病房(10.77%)、呼吸内科(10.77%)较常见;对多种抗菌药物的耐药率>70%;感染患者大多为年老体弱、基础疾病多、住院时间长且接受各种侵入性操作、感染前反复使用2种以上抗菌药物者;部分病例合并其他病原菌感染,以铜绿假单胞菌(34.55%)及嗜麦芽窄食单胞菌(20.00%)较多。结论鲍曼不动杆菌肺部感染患者病情重,对抗菌药物耐药率高,掌握其临床特点、感染分布及耐药规律,对临床预防与治疗尤为重要。

Objective To analyze the clinical characteristics and drug resistance of Acinetobacter baumannii （A. baumannii） pulmonary infection. Methods Clinical data of 65 cases of A. baumannii pulmonary infections in a hospital from June, 2006 to June, 2008 were analyzed. Results The incidence rate of A. baurnannii infections were high in general intensive care unit （ICU, 41.54%）, neurological ICU （29. 23%）, neurosurgical ICU （10. 77%）, and respiratory department（10. 77 %） ;Resistant rates to many kinds of antimicrobial agents were 〉70 %. The infected patients were almost aged, with many underlying diseases, with long hospitalization time and various invasive treatment, as well as receiving at least 2 kinds of antimicrobial agents before developing infection; some patients complicated with infections caused by the other pathogens, most were Pseudomonas aeruginosa （34. 55%） and Stenotrophomonas maltophilia （20. 00%） infections. Conclusion Patients with A. baurnannii infections are in serious condition, antimicrobial resistance is high, realization of the clinical characteristics, infection distribution and drug resistance pattern are important to prevent and treat infections.