乙肝患者血清ALT及乙肝病毒标志物与病毒含量的关系探讨

A study on the relationship between ALT,HBV markers,and HBV-DNA concentration in sera from patients with the hepatitis B virus

采用ELISA检测620例乙肝患者血清乙肝标志物,采用FQ-PCR检测HBV-DNA。发现单凭HBeAg阳性或单凭HBV-DNA阳性来判断乙肝患者的传染性,将会漏掉10%左右具有传染性的乙肝患者。在判断乙型肝炎患者的预后方面,HBV-DNA检测比血清标志物检测更敏感而特异,而PCR方法可定量检测病毒DNA的浓度,真实反映HBV的感染和复制状况。

Serum HBV markers were assayed using ELISA and the HBV-DNA concentration was determined with FQ-PCR in sera from 620 patients with the hepatitis B virus.About 10% of patients with an infection were overlooked based on patients deemed to be positive for HBeAg or for HBV-DNA.This study also showed that HBV-DNA concentration was more sensitive and faster than serum HBV markers in determining the prognosis of HBV.