摘要
采用SD大鼠慢性肾血管性高血压模型，高效液相和气－液色诣定量法测定脑细胞胺磷脂、游离脂肪酸（FreeFattyAcidFFA）组分变化．结果显示：1．高血压组脑细胞膜磷脂组分中PI显著低于对照组（P＜0．O5），PS、PE、PC，组分轻微下降（P＞0．05）．2．FFA组分中C20；4，C22；6水平显著高于对照组（P＜0.01，P＜0．O5），C18：0水平显著低于对照组（P＜0．05），C16：0和C18：1轻度降低（P＞0．05）．提示继发性高血压大鼠伴有脑细胞膜磷脂、FFA代谢障碍．
By using chronic renovascular hypertension model of Sprague-Dawley rats,different phospholipids (PLs),free fatty acid (FFA)contentS of brain cell membrane were determined in nometfnsive(n= 9)and hypertensive (n= 8) rats with high-performanc, chromatograpby (HPLC) and gaS-liquid chromatography (GLC) techniques. The date showed that: 1. phosphatidylinosltol (PI) in renovascular bypertensive groupwas found slgnificantly lower than that of normotensive group (P<0. 05), the levels of phosphatidylserine(PS), phospbatidylethanolamine (PE ), prosphatidylcholine (PC ) were not obviously different between these,two groups (P<0. 01 P<0. 05). 2. C20: 4(arachidonic acid),C22: 6(docosabeaenoic acid)levels increasedsignincantly(p>0.05),C18 :0(stearic acid) decreased obviously(P<0.05),and C16:0o(palmitic acid),C18: 1(oleic arid)decreased sightly from hypertensive group(p>0. 05) as compared with normotensive group.The tindings seem to reflect an abnormal metabolism or brain membrane PLs and FFA in experimental bypertensive rats.
关键词
高血压
脑
磷脂
游离脂肪酸
hypertension
brain
phospholipids
free fatty acids
rat
