摘要
采用荧光分光光度测定法，测定黑质区注射神经降压素及其抗血清对效状体等脑区多巴胺含量的影响。结果表明：（1）黑质区注射不同剂量的神经降压素后，纹状体内多巴胺含量较对照组明显增加，且呈明显的量效依赖关系，而下丘脑及大脑皮层内多巴胺含量无明显改变；（2）黑质区注射抗神经降压素血清后，级状体内多巴胺含且无明显改变。这提示，黑质区外源性神经降压素可增加效状体多巴胺的含量。
The effects of microinjection neurotensin (NT) and anti-NT serum into substantia nigra on the contents of dopamine (DA) were measured by fluorometry. The results were shown: (1) The contents of DA in the striatum was increased in a dose-dependent way by injection of NT into the substantia nigra, but there were no change in hypothalamus and cerebral cortex; (2) The contents of DA in striatum had no change by injection of anti-NT serum into the substantia nigra. These results suggest that exogenous NT in substantia nigra can increase the content of DA from the striatum.
基金
山东省卫生厅赞助
