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脑内转移脑源性神经营养因子基因促进穹窿切断大鼠神 … 被引量:2

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摘要 将人类全长脑源性神经营养因子(BDNF)基因克隆入逆转病毒效表达载体,导入到包装细胞,得到产生高滴度复制缺陷在病毒的产毒包装细胞株,将这种细胞移植到穹窿-海马伞切除的大鼠脑内,观察其对隔海马系统胆碱能神经纤维侧枝长芽的促进作用及其功能恢复情况,结果显示,产毒包装细胞株移植可明显促进空间学习记忆功能的恢复,表现为在Morris水迷宫平台搜寻任务中的平均逃避潜伏期较对照组明显缩短(P〈0.01)。
机构地区 郧阳医学院
出处 《中国神经科学杂志》 CSCD 1998年第3期127-133,145,共8页
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