RANKL与骨代谢

RANKL and bone metabolism

核因子κB受体活化因子配基(receptor activator of NF-κB Ligand,RANKL)是一种Ⅱ型跨膜蛋白,是目前发现的惟一具有诱导破骨细胞分化、发育、发挥功能的因子。NF-κB受体激活子(receptor activatorof NF-κB,RANK)是一种Ⅰ型跨膜蛋白,是RANKL的惟一受体,是RANKL发挥功能的关键。骨保护蛋白(osteoprotegerin,OPG)是一种分泌型糖蛋白,与RANKL竞争性与RANK结合抑制骨吸收、促进骨形成。近年来通过许多对RANKL的研究发现,它不仅在骨质疏松症的发病中起重要作用,而且也在骨代谢过程中受多种因素影响,并为骨质疏松症及其他骨骼疾病的治疗开辟了广阔的前景。

Receptor activator of NF-KB Ligand, a type II transmembrane protein, is so far the only one factor that can induce differentiation, maturation of osteoclastgenesis and mediating its function. Receptor activator of NF-t^B, a type ] transmembrane protein, is the unique receptor of RANKL, and it is very key for RANKL to educe function. Osteo- protegerin is a secretary glucoprotein which can link to RANK and inhibit bone resorption, enhance bone formation. Recently, many studies indicate that RANKL can not only play an important role in the pathogenesis of osteoporosis, but al- so be influenced by many factors, and open up broad prospect for the therapy of osteoporosis and other bone diseases.