老年无症状性脑梗死认知功能障碍及其影响因素

The Study of Cognitive Dysfunction in Old Patients with Silent Brain Infarction and its Related Factors

目的:探讨无症状脑梗死(SBI)患者认知功能障碍发病率及其影响因素。方法:随机选取78例SBI患者(DBI组)和78例性别、年龄及所伴有的慢性病相匹配的对照者(对照组)分别进行简易精神状态检查(MMSE)量表测验、画钟测验(CDT)、汉密尔顿抑郁(HAMD)量表检查,并对检测结果进行比较。分析SBI患者的年龄、病灶数、抑郁程度、血压,血糖及血脂对其认知功能的影响。结果:SBI认知功能障碍发生率(53.8%)明显高于对照组(33.3%),其MMSE、CDT评分明显低于对照组。结论:SBI患者出现认知功能障碍非常普遍,其认知功能下降与SBI患者年龄、脑梗死病灶数及是否伴有抑郁高血压、糖尿病及高血脂显著相关。

Objective：To study cognitive dysfunction in patients with silent brain infarction and its related factors.Methods：78 patient with silent brain infarction（SBI）were tested by the scale of mini mental state examination（MMSE）and Clock draw test（CDT）;Hamilton Depression Rating Scale for Depression（HAMD）were applied to evaluate its depressive symptoms.the result were analyzed to evaluate the influence of age,number of infarction,depression,hypertension,blood sugar and blood lipids on cognitive function respectively.Results：The rate of cognitive dysfunction was significantly higher（53.8% vs 33.3%）.The score of MMSE and CDT in SBI group was significantly lower than that in control group.Conclusion：the rate of cognitive dysfunction was high in the patients with SBI.The related factors include age,number of infarction,depression,hypertension,diabetes,high blood lipids.