自动室壁分区运动分析与全方位M型超声心动图评价缬沙坦对高血压左心室重构及心脏整体功能的影响

Effects of valsartan on left ventricular remodeling and cardiac function in patients with essential hypertension using echocardiography with automated segmental motion analysis and free angle model

目的探讨自动室壁分区运动分析（ASMA）与全方位M型超声心动图（FAM）技术评价血管紧张素Ⅱ受体拮抗剂缬沙坦对原发性高血压左室重构及心脏整体功能的影响。方法原发性高血压患者178例，应用缬沙坦80mg／d口服治疗，疗程12个月。观察治疗过程中患者血压及症状体征的变化情况，并分别在治疗前及治疗后每3个月分阶段应用ASMA—FAM技术观察心脏形态学及心脏整体功能变化情况。结果在治疗缬沙坦2周后血压开始下降，5周后趋于平稳；心腔径、室壁厚度及左室质量指数等在治疗3月后开始降低（P〈0．05），6个月至1年后明显下降（P〈0．01）并趋于稳定，左室壁运动状态及心脏整体功能均随之明显改善（P〈0．01）。结论缬沙坦能有效逆转原发性高血压所导致的左室重构，明显改善心脏整体功能，ASMA—FAM能全面、客观地评价心脏结构、室壁运动状态及心脏整体功能情况。

Objective To assess the effects of valsartan on left ventricular remodeling and cardiac functions in patients with essential hypertension using echocardiography with automated segmental motion analysis（ASMA） and free angle model（FAM）. Methods The parameters about the cardiac morphology and function of the 178 cases with essential hypertension were observed before and per three months （ total about twelve months ） after valsartan treated （80 mg/day） using echocardiography with ASMA-FAM, and the blood pressure values and patients＇ symptoms were observed at the same time. Results The patients＇ symptoms were improved, and the values of the patients blood pressure were decreased gradually after using valsartan two weeks,and they were to steady after five weeks. The values of left ventricle diameter, wall thickness, and left ventricular mass index were be decreased after treated six months（ P〈0.05） ,and they were be decreased obviously after treated one year（ P 〈0.01） ,the left ventricular wall kinestate, cardiac functions were improved （ P 〈0.01 ）. Conclusions The left ventricular remodeling and the cardiac functions in patients with essential hypertension are improved obviously after using valsartan treated twelve months. The cardiac structures, left ventricle wall kinestate, and cardiac functions can be evaluated overall and objectively using echocardiography with ASMA-FAM.