儿童颅内未成熟畸胎瘤（附30例报告）

Intracranial immature teratomas in children （30 cases report ）

目的探讨儿童颅内未成熟畸胎瘤的临床特征、治疗策略和预后。方法回顾性分析30例经手术及病理证实的未成熟畸胎瘤患儿的临床资料，26例获得随访。结果19例术前行血和（或）脑脊液肿瘤标记物（AFP，B—HCG）检测，12例阳性。初次手术肿瘤全切15例，近全切7例，大部切除6例，部分切除2例。随访患儿中，23例行辅助治疗。患儿半年、1年及2年的生存率分别为80％、69％、60％，患儿的存活时间与肿瘤的切除程度差异有统计学意义（P〈0．05）。结论肿瘤标记物的检测有助于诊断。手术是首选的治疗措施，应尽量做到全切。术后应辅以放、化疗。

Objective To investigate the clinical features, therapeutic strategies and prognosis of intraeranial immature teratomas in children. Methods A retrospective review of 30 children with immature teratomas pathologically confirmed by surgical resection was performed. 26 cases were followed up. Results Serumand （or） cerebrospinal fluid tumor markers （AFP, β -HCG） were tested preoperatively in 19 cases, with positive result in 12 cases. At the initial operations, total, gross - total, sub - total and partial removal of the tumors were achieved in 15, 7, 6 and 2 cases respectively. Among the followed - up children, 23 cases received adjuvant therapies. The half- year, 1 -year and 2 -year survival rates were 80%, 69% and 60% respectively. There was a significant correlation between the tumor resection extent and patient＇s survival. Conclusion The tumor markers are useful for diagnosis. Surgery is the therapeutic priority and total resection should be achieved as far as possible. Postoperative radiotherapy and chemotherapy should be routine adjuvant treatment measures.