复方苦参注射液对晚期非小细胞肺癌化疗的增强作用

Enhancing effect of compound Kusheng injection in combination with chemotherapy for patients with advanced non-small cell lung cancer

目的探讨复方苦参注射液在Ⅲ、Ⅳ期非小细胞肺癌（NSCLC）化疗中的作用。方法经病理学或细胞学检查确诊的Ⅲ、Ⅳ期NSCLC患者随机分为试验组与对照组。试验组144例，采用复方苦参注射液联合长春瑞滨＋卡铂方案化疗；对照组142例，单纯采用长春瑞滨＋卡铂方案化。每3周为1个周期，化疗4个周期。每2个周期评价疗效，监测治疗前后患者外周血血红蛋白（HB）、白细胞（WBC）、血小板（PLT）、T细胞亚群及血清免疫球蛋白（Ig）含量变化。结果试验组和对照组的有效率分别为48．6％和45．1％（P〉0．05），疾病进展（PD）率分别是6．9％和15．5％（P〈0．05）。试验组胃肠道反应和骨髓抑制较对照组减轻，差异有统计学意义（Jp〈0．05）。试验组治疗前后co；分别为（26．71±5．41）％和（17．80±4．29）％，c04／co／分别为1．58±0．24和2．04±0．13；而对照组治疗前后CDs^＋分别为（33．16±4．36）％和（35．84±5．22）％，CD4^＋／CD8^＋分别为1．13±0．12和1．11±0．21，两组比较，差异有统计学意义（P〈0．05，P〈0．01）。且试验组化疗后KPS评分明显高于对照组（P〈0．01）。化疗后试验组血清IgM含量为（1．43±0．29）g／L，IgG含量为（18．96±4．75）g／L，与对照组差异有统计学意义（P〈0．05）。结论复方苦参注射液联合长春瑞滨＋卡铂方案治疗Ⅲ、Ⅳ期NSCLC疗效较好，患者不良反应轻，具有提高机体的免疫功能和改善患者的生活质量的作用。

Objective To explore the enhancing effect of compound Kusheg injection in chemotherapy for patients with stage Ⅲ and Ⅳ non-small cell lung cancer （NSCLC）. Methods A total of 286 patients with advanced NSCLC were enrolled in this study. The patients were treated with either compound Kusheng injection in combination with NP （NVB ＋ CBP ） chemotherapy （vinorelbine and carboplatin, n = 144）, or with NP （ NVB ＋ CBP） chemotherapy alone （ n = 142）. The chemotherapy was performed for 4 cycles of 3 weeks, and the therapeutic efficacy was evaluated every 2 weeks. The following indicators were observed： levels of Hb, WBC, PLT and T cell subpopulations in blood, serum IgG level, short-term efficacy, adverse effects and quality of life. Results The gastrointestinal reactions and the myelosuppression in the combination chemotherapy group were alleviated as compared with the chemotherapy alone group, showing a significant difference （ P 〈 0. 05 ）. CDs^＋ cells were markedly declined in the combination chemotherapy group, and the CD4/CD8 ratio showed an elevation trend in the chemotherapy alone group. The KPS scores and serum IgM and IgG levels were higher in the combination chemotherapy group than those in the chemotherapy alone group （ P 〈 0.01 and P 〈 0.05 ）. The serum lgA levels were not significantly different in the two groups. Condusion The compound Kusheng injection plus NP chemotherapy regimen shows better therapeutic effect, reduces adverse effects of chemotherapy and improves the quality of life in patients with stage m and IV NSCLC.