游离前列腺特异性抗原与总前列腺特异性抗原比值在前列腺癌诊断中的作用

The Usefulness of F/T Ratio for Detecting Prostate Cancer

目的:探讨总前列腺特异性抗原(T-PSA)为4.0～10.0ng·mL-1时,游离前列腺特异性抗原与总前列腺特异性抗原比值(F/T比值)在前列腺癌(PCa)诊断中的作用。方法:检测289例良性前列腺增生(BPH)及可疑前列腺癌患者的血清T-PSA及游离PSA(F-PSA)值,对T-PSA为4.0～10.0ng·mL-1的前列腺穿刺活检患者进行随访。采用单因素方差分析方法分析T-PSA为4.0～10.0ng·mL-1时F/T比值在前列腺癌诊断中的作用。结果:在T-PSA为4.0～10.0ng·mL-1时,BPH组与PCa组的F/T比值差异无统计学意义(F=0.73,P=0.397>0.05)。结论:在T-PSA为4.0～10.0ng·mL-1时,BPH组和前列腺癌组的T-PSA无显著差异(P>0.05),F/T比值也无显著差异(P>0.05)。

Objective：We investigated the usefulness of F/T ratio for detecting prostate cancer in patients with T-PSA between 4.0 and 10.0ng.mL-1. Methods：Collecting serum T-PSA and F-PSA of patients who visited our hospital for BPH and suspicious prostate cancer Between September 2007 and November 2009,Patients who underwent prostate biopsy with T-PSA between 4.0 and 10.0 ng·mL-1 were followed up and analyzed in terms of the ability of F/T ratio to predict prostate cancer. Simple variance analysis was used for analyzing the the usefulness of F/T ratio for detecting prostate cancer in patients with T-PSA between 4.0 and 10.0 ng·mL-1.Results：The difference in F/T ratio between the two groups was not significant in men with T-PSA between 4.0 and 10.0 ng·mL-1.（F=0.73,P=0.3970.05）.Conclusions：Both the total PSA and the F/T ratio were not significantly differentiated between patients with prostate cancer and patients with BPH in men with T-PSA between 4.0 and 10.0 ng.mL-1（P0.05,P0.05）,The F/T ratio being an unreasonable marker of total PSA to distinguish BPH from prostate cancer in patients with T-PSA between 4.0 and 10.0 ng·mL-1.