摘要
高迁移率蛋白1(HMGB1)是一种非组核蛋白,正常情况下,作为细胞核染色质的组分之一,调节基因的重组、修复、转录等生命活动。坏死细胞或活化的免疫细胞可通过被动或主动形式,将细胞核内的HMGB1释放到细胞外。细胞外的HMGB1与相应受体结合后可发挥促炎和组织修复双重作用。目前,HMGB1在多种感染/非感染性炎症性疾病中的作用已得到证实,它已成为炎症性疾病治疗的新靶点之一。
High mobility group box 1（HMGB1）is a non-histone nuclear protein.In normal condition,HMGB1 acts as a component of chromosome,and regulates the activities of recombination,recondition and transcription of DNA.HMGB1 could be released by necrotic cells or actived immunocytes passively or actively.Extracellular HMGB1 combines with many receptors,and then causes dual function of inflammatory and tissue repair.Recently,the effect of HMGB1 in inflammatory diseases has been proved.And it has been one of the new therapeutic target of inflammatory diseases.
出处
《医学综述》
2010年第9期1303-1306,共4页
Medical Recapitulate
关键词
高迁移率蛋白1
乙酰化
炎性反应
High mobility group box 1
Acetylation
Inflammatory reaction
