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内皮抑素与肺发育关系的研究进展 被引量：1

Endostatin in the Development of Lungs
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摘要 微血管和肺泡的发育在肺发育过程中起着重要作用,而微血管的发育受生长调节因子血管内皮生长因子和内皮抑素的调节。内皮抑素是一种内源性的血管生成抑制因子,抑制新生血管的生成,影响肺发育的成熟,与某些肺疾病的发生密切相关。现就内皮抑素的作用机制,对肺发育及肺疾病的影响及其临床应用前景予以综述。 The development of the alveolus and capillary plays an important role in lung development.Vascular endothelial growth factor（VEGF）,endostatin（ES）,and two growth regulatory factors affect the development of the capillary.Endostatin,as an andogenoua angiogenesis inhibitive factor,can inhibit angiogenesis,affect the maturity of the lung and be related to some pulmonary disease.Here,the mechanism and influence of the endostatin on the development of the lung and pumonary disease were reviewed as well as the clinical application in the future.
作者 肖芳芳 黄宇戈
机构地区 广东医学院附属医院儿科
出处 《医学综述》 2010年第9期1306-1308,共3页 Medical Recapitulate
关键词 内皮抑素 肺发育 血管内皮生长因子 Endostatin Lung Development Vascular endothelial growth factor
分类号 R563 [医药卫生—呼吸系统]
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参考文献16

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二级参考文献27

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共引文献7

同被引文献34

  • 1高鸿美,焦光宇,毕涛,李胜岐.脂多糖致大鼠急性肺损伤早期I型前胶原羧基端肽及转化生长因子β_1的表达[J].中华结核和呼吸杂志,2007,30(9):703-704. 被引量：2
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  • 4KIM D H, KIM H S. Serial changes of se'um endostatin and an- giopoietin- 1 levels in preterm infants witk severe brotlchopulmo- nary dysplasia and subsequent pulmonary artery hypertension [ J ]. Neonatology, 2014, 106( 1 ) : 55 - 61.
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医学综述
2010年 第9期

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