血浆对氧磷酯酶1活性在溃疡性结肠炎中的变化及临床意义

Change of plasma paraoxonase 1 activity in patients with ulcerative colitis

目的探讨对氧磷酯酶1(PON1)活性在溃疡性结肠炎(UC)中的变化及临床意义。方法分别测定44例活动期UC患者、23例缓解期UC患者及32例健康对照者的血浆PON1、C-反应蛋白(CRP)及丙二醛(MDA)含量,分析其相关性。结果活动期及缓解期UC组血浆CRP、MDA含量显著高于对照组(P<0.05),血浆PON1活性显著低于对照组(P<0.05)。活动期患者组血浆CRP、MDA含量显著高于缓解期患者组(P<0.05),血浆PON1活性显著低于缓解期患者组(P<0.05)。UC患者组对氧磷酯酶1活性与MDA及CRP水平呈负相关(r=-0.358,P<0.01,r=-0.422,P<0.01)。结论UC患者PON1活性显著降低,增加的氧自由基(OFR)导致致氧化环境可能使血浆PON1活性显著降低。

Objective To investigate the change of plasma antioxidant enzyme paraoxonase 1（PON1）activity in patients with ulcerative colitis（UC）,as well as its clinical significances.Methods Plasma PON1 activity,malondiadehyde（MDA） and C-reactive protein（CRP） levels were analysed in 44 case of active ulcerative colitis,23 case of ulcerative colitis in remission and 32 case of control.Correlation analysis was made between these variables.Results Plasma PON1 activity was lower and MDA,CRP levels was higer in the active and remission patients groups than the control.When active subgroups were compared with the remission group,there was a statistically difference between each parameter.Plasma PON1 activity was significantly lower,while CRP and MDA levels was significantly higer in the active UC group than the remission UC group.The analysis of linear correlation showed PON1 was negatively correlated with MDA（r=-0.358,P0.01）,CRP（r=-0.422,P0.01） in patients with ulcerative colitis.Conclusion Plasma PON1 activity was significantly decreased in patients with ulcerative colitis.Increased oxygen free radicals（OFR） levels in ulcerative colitis may result in a pro-oxidation environment,which in turn could result in decreased antioxidant paraoxonase 1 activity.