摘要
目的探讨卒中后抑郁对急性脑梗死预后的影响。方法68例卒中后抑郁患者随机分成两组:对照组30例,给予抗血小板、改善脑循环治疗;治疗组35例,给予抗血小板、改善脑循环治疗同时给予帕罗西汀20mg抗抑郁治疗,持续4周。观察两组脑梗死后伴抑郁患者治疗前、后神经功能、Barthel指数及抑郁评分的变化。结果治疗组经4周抗抑郁治疗,神经功能缺损评分(NIHSS)由(8.6±2.1)减少为(3.4±1.5),Barthel指数由(27.6±11.1)升高为(68.0±15.1),抑郁评分(HAMD)由(27.8±4.4)下降为(9.7±6.9),与对照组比较差异有统计学意义(P<0.05)。结论卒中后抑郁对急性脑梗死预后有一定影响,对抑郁进行干预有助于改善预后。
Objective To probe into the effect of post stroke depression（PSD） on prognosis of acute cerebral infarction.Methods 68 cases of post stroke depression were randomly allocated to two groups： control group（30 cases） accepted anti-platelet drug and drugs improving cerebral circulation and treatment group（35 cases） received anti-depression treatment with paroxetine 20mg daily for four weeks besides above-mentioned treatment.Two groups were observed change of neurologic deficit scale（NIHSS） and Barthel index and depression scale before and after treatment.Results NIHSS and HAMD of treatment group decrease form（8.6±2.1）to（3.4±1.5）and from（27.8±4.4）to（9.7±6.9）;Bathel index increase from（27.6±11.1） to（68.0±15.1）after four weeks of treatment.This difference comparing with control group was significant（P0.05）.Conclusion PSD have an effect on prognosis of cerebral infarction,intervention for PSD is helpful to stroke prognosis.
出处
《四川医学》
CAS
2010年第4期457-459,共3页
Sichuan Medical Journal
关键词
卒中后抑郁
急性脑梗死
预后
post stroke depression
acute cerabral infaction
prognosis
