我国围产儿先天畸形危险因素的Meta分析

Meta-analysis of Risk Factors on Congenital Malformation in China

目的探讨我国围产儿先天畸形发生的部分危险因素,为该病的防治提供重要线索。方法应用Meta分析方法对国内2000-2009年间发表的10篇关于先天畸形危险因素病例对照文献进行综合分析。结果孕期被动吸烟、出生缺陷家族遗传史、孕早期感染、流产史、孕早期服药、孕期接触污染、负性精神刺激、妊娠剧烈呕吐、孕期营养不良九个研究因素的合并OR及95%可信区间分别为2.820（1.490-5.332）、3.997（2.055-4.305）、5.225（2.679-10.190）、2.394（1.182-6.652）、3.130（1.902-5.153）、3.432（1.533-6.723）、1.707（1.305-2.232）、5.371（1.511-19.100）、3.911（3.449-4.441）。结论九个因素均为先天畸形发生的危险因素。

Objective To evaluate the main risk factors on congenital malformation and to provid evidence for its prevention. Methods The results on the risk factors of birth defect from 2000-2009 were analyzed synthetically by Meta-analysis. Results The pooled OR values and 95%CI of smoking during pregnancy,family history of congenital defect,complications in early pregnancy,spontaneous abortion,medicine use in early pregnancy,exposure to damage chemicals in pregnancy,adverse mental stimulus,vomiting greatly during pregnancy,malnutrition during pregnancy were 2.82（1.490-5.332）,3.997（2.055-4.305）,5.225（2.679-10.190）,2.394（1.182-6.652）,3.130（1.902-5.153）,3.432（1.533-6.723）,1.707（1.305-2.232）,5.371（1.511-19.100）,3.911（3.449-4.441）respectively.Conclusion Smoking during pregnancy,family history of congenital defect,complications in early pregnancy,spontaneous abortion,medicine use in early pregnancy,exposure to damage chemicals in pregnancy,adverse mental stimulus,malnutrition during pregnancy are main risk factors of congenital malformation in Chinese.