衡阳市非酒精性脂肪肝患病率及危险因素分析

Analysis of the Prevalence Rate of Nonalcoholic Fatty Liver Disease and its Risk Factors in Hengyang City

目的了解健康人群中非酒精性脂肪肝病(NAFLD)患病率及其相关危险因素,为防治NAFLD提供依据。方法以衡阳市南华大学第二附属医院健康体检的3261例人群为研究对象,以是否患NAFLD将研究对象分为NAFLD组和对照组。收集相关体检资料进行显著性分析。结果NAFLD总检出率为16.6%,有明显的性别、年龄差异;不同职业人群NAFLD患病率有所不同;NAFLD组各危险因素检出率均高于对照组;除高密度脂蛋白外,NAFLD组各临床指标均值均高于对照组;Logistic回归分析结果显示年龄、体重指数、甘油三酯、尿酸、丙氨酸氨基转移酶、高密度脂蛋白与NAFLD的发生密切相关。结论肥胖、年龄、甘油三酯、尿酸和丙氨酸氨基转移酶活性升高是NAFLD的危险因素,高密度脂蛋白是其保护因素,应注意NAFLD的防治。

Objective To investigate the prevalence rate of nonalcoholic fatty liver disease and its risk factors among the people taken health examination and provide scientific basis for prevention and treatment. Methods The medical examination results of 3 261 cases were collected for statistical analysis from the Second Affiliated Hospital of University of South China. Results The total incidence of nonalcoholic fatty liver disease in our study was 16.6%. There ate significant differences between gender groups and among age groups. The incidence rate of NAFLD is varied form different occupations and the risk factors for NAFLD group had higher detection rate. In addition to high - density lipoprotein, all clinical indicators of NAFLD group are higher than that of control. Multiple logistic regression analysis revealed that the risk factors of NAFLD including AGE, BMI, TG, UA, ALT, HDL- C and hypertension were highly relative to NALFD. Conclusion The risk factors for NAFLD are obesity, age ,triglycerides, uric acid and alanine amino - transferase activity increased. HDL- C is the protective factor for NALFD which should be paid attention to for NAFLD prevention and treatment.