乳腺癌组织中血管内皮生长因子与雌激素受体、孕激素受体及人类表皮生长因子的关系

The Correlations of Vascular Endothelial Growth Factor and Estrogen Receptor,Progesterone Receptor,Human Epidermal Growth Factor Receptor Expression in Breast Cancers Tissue

目的探讨乳腺癌组织中人类表皮生长因子(VEGF)与雌激素受体(ER)、孕激素受体(PR)、人类表皮生长因子(Her-2)的关系,进而分析VEGF在乳腺癌各分子分型中的表达是否有差异性。方法应用免疫组化方法检测50例病理证实乳腺癌组织中VEGF、ER、PR、Her-2的表达。结果50例乳腺癌患者中VEGF、ER、PR、Her-2的阳性表达率分别为64%、60%、52%、70%;VEGF与肿瘤TNM分期正相关(r=0.380),ER、Her-2与肿瘤TNMA分期无明显相关性;VEGF与ER、PR呈负相关(r=-0.343,-0.330),与Her-2表达呈正相关(r=0.290),在不同乳腺癌分子分型中的表达有统计学意义(P=0.03)。结论VEGF是判断乳腺癌预后的重要指标之一,可以成为三阴性乳腺癌的治疗靶点。

Objective To investigate the correlations of vascular endothelial growth factor（VEGF） and estrogen receptor（ER）,progesterone receptor（PR）,human epidermal growth factor receptor（Her-2）expression in fifty breast cancer patients,then use these data to investigate the variability and correlations of VEGF expression in different molecular classification.MethodsUse immunohistochemistry to detect the expression of VEGF,ER,PR,Her-2 in the fifty breast cancer issue which have been proved by pathology.Results In the 50 breast cancers,the positive rate of VEGF,ER,PR,HER-2 is 64%,60%,52%,70%;The expression of VEGF is significantly positive correlated to the pathogistological type of tumors（TNM）（r=0.380）,ER,HER-2 expression is not signigicantly correlated to the pathogistological type of tumors（TNM）;The expression of VEGF is negative correlated with ER and PR expression（r=-0.343,-0.330,respectively）,is significantly positive correlated to Her-2,is correlated with the prognosis of different types（P=0.03）.Conclusion VEGF expression is one of the key factors effecting the prognosis of breast cancers and its relative therapies could be used to treat the triple negative breast cancer（TNBC） typeof breast cancer molecule classification.