氟哌啶醇治疗脑出血后急性脑综合征的临床研究

Clinical Observations of Haloperidol on Treatment of Acute Brain Syndrome after Intracerebral Hemorrhage

目的探讨氟哌啶醇治疗脑出血后急性脑综合征的疗效。方法将48例患者按入院时间分为2组,2006年1月至2009年6月入院的脑出血急性脑综合征患者25例为治疗组,给予氟哌醇5 mg肌内注射,视病情4～6 h后再注射1次;2002年1月至2005年12月入院的脑出血急性脑综合征患者23例为对照组,给予氯丙嗪25 mg肌内注射,每12小时1次,连用2 d。治疗后21 d对2组患者的卒中量表(NI HSS)评分及疗效进行比较。结果治疗组患者治疗后发生肺部感染的机会大为减少;治疗组有效率92.0%,对照组有效率73.9%,2组比较差异有统计学意义(P<0.05);NI HSS评分治疗组明显低于对照组(P<0.05)。结论氟哌啶醇是治疗脑出血后急性脑综合征的一种安全有效的药物。

Objective To investigate the efficacy of Haloperidol in the treatment of acute brain syndrome after intracerebral hemorrhage.Methods Forty-eight patients were divided into two groups by the time of admission.In treatment group 25 cases with acute brain syndrome after intracerebral hemorrhage admitted from the January in 2006 to the June in 2009 were muscle injected 5 mg Haloperidol,and after 4 to 6 hours 5 mg was used again;In control group,23 cases with acute brain syndrome after intracerebral hemorrhage admitted from the January in 2002 to the December in 2005 were muscle injected 25 mg Chlorpromazin.Once every 12 hours,2 days used in conjunction.Then the two groups were compared with the stroke scale（NIHSS） and the efficacy after the 21 days of treatment.Results The patients of the treatment group greatly reduced the chances of pulmonary infection after treatment.The effective rate of the treatment group is 92.0%,yet it was 73.9% in the control group.Compared with the two groups,there was significant difference（P〈0.05）.NIHSS Score of the treatment group is significantly lower than that of the control group（P〈0.05）.Conclusion In the treatment of acute brain syndrome after cerebral hemorrhage,Haloperidol is a safe and effective drug.