急性胰腺炎患者血清瘦素、NO变化的临床意义

Changes of Serum Levels of Leptin and NO in Acute Pancreatitis Patients

【目的】探讨急性胰腺炎（AP）患者血清瘦素和一氧化氮（NO）变化的临床意义。【方法】采用放射免疫法测定48例AP患者急性期和恢复期的血清瘦素水平，同时采用硝酸还原酶法检测NO水平。【结果】AP急性期组血清瘦素及NO水平显著高于AP恢复期组及正常对照组（P均〈0．001），AP恢复期组血清瘦素及NO水平与正常对照组比较无明显差异（P均〉0．05）；AP患者血清瘦素与体重指数呈正相关（γ=0．685，P〈0．01）；与脂肪含量呈正相关（γ=0．456，P〈0．01）；与血清NO水平呈正相关（γ=0．474，P〈0．01）。【结论】血清瘦素和NO与AP的病情发展、转归有密切关系；瘦素对AP的保护作用与NO密切相关。

[Objective] To investigate the changes of serum leptin and nitric oxide（NO） of patients with acute pancreatitis（AP） and their clinical significances. [Methods]The serum leptin level was measured in 48 patients with AP by immunoluminometric assay, and the level of NO was measured by nitrate reductase method. [Results]The serum levels of leptin and NO of the convalescence group were significantly higher than those of the acute stage group and contrast group（all P 〈0. 001）. Serum leptin ievel of patients with AP was positively correlated with BMI, % Fat and NO. [Conclusion] There is close relation between the serum levels of leptin or NO and the progression and turnover of AP. The protective effect of leptin on AP is closely related with the serum NO level.