结直肠癌术后肝转移的影响因素分析

Analysis of the Risk Factors of Liver Metastasis after Surgery for Colorectal Cancer

【目的】探讨结直肠癌术后肝转移与其临床病理因素之间的关系，分析其在结直肠癌术后肝转移中的意义。【方法】收集行根治性手术治疗的结直肠癌病例700例，其中结直肠癌术后肝转移170例，无肝转移530例，选择性别、年龄、肿瘤直径、分化程度、Dukes分期、组织学类型、淋巴结转移等临床病理因素分组用χ^2检验进行组间分析。【结果】Dukes分期和淋巴结转移两组中肝转移发生率的差别具有显著性（P〈0．05），其中DukesA、B、C期肝转移的发生率分别为17．2％、17．4％、36．3％。有淋巴结转移者肝转移的发生率为36．3％，无淋巴结转移者肝转移发生率为17．3％。【结论】肿瘤分期和淋巴结转移是影响结直肠癌肝转移的重要因素。肿瘤病理分期越晚者更易发生肝转移，有淋巴结转移者术后肝转移发生率明显高于无淋巴结转移者。

[Objective] To explore the relationship between liver metastasis after surgery for colorectal cancer and its risk factors. [Methods] Seven hundred cases of colorectal cancer who underwent radical surgery were studied. Of all cases, 170 cases had liver metastasis and 530 cases did not have after surgery. The patient＇s gender and age, the size and differentiation of the tumor, Dukes stage and histological type of the tumor, lymph node involvement were analyzed. [Results] There was difference in the incidence of liver metastasis in patients of colorectal cancer at different Dukes stage and with different lymph node metastases（ P 〈0. 05）. The incidence of liver metastasis for colorectal cancer of Dukes A, B and C was 17.2%, 17.4% and 36.3%, respectively. The incidence of liver metastasis in patients with lymph node metastases was 36.3 % and in patients without lymph node metastasis was 17.3 %. [Conclusion] Dukes stage and lymph node metastasis are important factors related to liver metastasis of colorectal cancer. Liver metastasis occurred much more in patients at advanced tumor stage. The incidence of liver metastasis of patients with lymph node metastasis is significantly higher than that of patients without lymph node metastasis.