血清唾液酸检测在恶性肿瘤诊治中的临床研究

Serum sialic acid levels in diagnosis and monitoring of malignant tumor

检测肿瘤科收治的366例恶性肿瘤患者、40例良性疾病患者及40例健康人的血清唾液酸，并对恶性肿瘤组中277例患者进行治疗前、后唾液酸监测。恶性肿瘤患者血清唾液酸含量明显高于健康者（P〈0．01），良性疾病者与健康者之间差异无统计学意义（P〉0．05）。治疗后病情稳定或好转的肿瘤患者血清唾液酸水平明显下降，而恶化或转移者其水平无明显变化或有上升趋势。病情稳定或好转的恶性肿瘤患者前3个月血清唾液酸水平变化明显，第4—6个月变化平稳；少数患者病情变化时唾液酸含量也相应有变化。

Serum sialic acid （SA） levels were detected by neuraminidase method in 366 patients with malignant tumor, 40 patients with benign diseases and 40 healthy subjects. For 277 malignant tumor patients, serum SA levels were monitored before and after treatment. The serum SA levels in malignant tumor group were significantly higher than those in benign diseases and control groups （P 〈0. 01 ）, but there were no differences between normal and benign groups （P 〉 0. 05 ）. Serum SA levels were decreased in malignant tumor patients with remission and stable disease after treatment. In remission or stable patients the decrease of serum SA levels occurred in the first three months and no changes were found from the fourth to sixth month; meanwhile SA levels were elevated in patients with instable condition.