本院2005～2008年度药品不良反应报告分析

Analysis of Adverse Drug Reactions from 2005～2008 in Longhu People's Hospital

目的分析本院药品不良反应（ADR）发生的原因及特点，为临床安全、合理用药提供依据。方法对2005—2008年度本院上报的116份药品ADR报告进行统计分析，评价药品不良反应的因果关系。结果116例患者中，因果关系评价肯定8例，很可能61例，可能46例，待评价1例。其中治愈109例，占93．97％；好转6例，占5．17％；有后遗症1例，占0．86％。药品不良反应中抗菌药物居首位，静脉滴注是主要的给药途径，皮肤损害是最常见的临床表现。结论医院应加强管理，重视药品不良反应监测，使临床用药更合理、安全。

Objective To analyze causes and characters of adverse drug reactions occurred in Longhu People＇ s hospital, so as to provide reference for clinical prescription. Methods The causes and characters of 116 adverse drug reactions reports from 2005 ~ 2008 were analyzed. Results Within 116 reports, the cause and effect relationship was define in 8 cases, probable in 61 cases, possible in 46 cases, and under evaluation in 1 case. And there were 109 cases （93.97%） recovered completely, partly in 6 cases （5.17%）, sequelae in 1 case（0.86% ）. The most commonly used drugs in those cases were antibiotics. Intravenous infusion was the most commonly used route of administration. And cutaneous symptom was the most common clinical manifestation. Conclusion More restrict action should be applied to monitor drug prescription and adverse drug reaction, so as to ensure the safety of clinical drug application.