虎金颗粒对免疫性肝纤维化大鼠肝功能和肝纤指标的影响

Effect of Hujin Granule on Liver Function and Fibre Index of Rats with Immune Hepatic Fibrosis

[目的]探讨虎金颗粒对免疫性肝纤维化模型大鼠肝功能和血清中肝纤指标的变化的影响。[方法]用猪血清腹腔注射诱导免疫性肝纤维化模型,并用不同剂量的虎金颗粒进行干预,用全自动生化分析仪测定肝功能,用放射免疫分析法测定血清肝纤指标。[结果]猪血清诱导的肝纤维化大鼠血清中AST、ALT、HA、LN、IV-C和PCⅢ含量均明显升高,虎金颗粒对上述指标有一定的逆转作用,并能升高血清中白蛋白含量。[结论]虎金颗粒对免疫性肝纤维化有一定的防治作用,能降低肝纤维化程度,同时有效减轻肝细胞损伤,改善肝功能。

[Objective] To explore the effect of Hujin Granule on liver function and serum fiber index of rats with immune hepatic fibrosis.[Method] Make abdominal injection with pig serum to induce immune hepatic fibrosis model,make intervention with different dosages of the Granule,measure liver function with automatic bio-chemical analyzer,and test serum hepatic fibrosis index with radio-immune analyse.[Result] The AST,ALT,HA,LN,IV-C and PCⅢ contents in rats serum with hepatic fibrosis induced with pig serum rose obviously,the Granule had definite reversion to the indexes above and could raise albumin content in serum.[Conclusion] Hujin Granule has definite prevention to immune liver fibrosis,can reduce fibrosis degree,meanwhile effectively decrease liver cell injure and improve liver function.