类胰岛素生长因子轴与儿童生长障碍
摘要
类胰岛素生长因子(IGFs)又称生长介素,是一组生长激素(GH)依赖性多肽,其主要功能是介导GH的蛋白同化作用和促有丝分裂作用.现就IGFs的结构、受体、结合蛋白及其临床意义综述如下.
参考文献12
-
1Rosenfeld RG. Disorders of growth hormone and insulinlike growth factor secretion and action. In: Sperlinng MA,Pediatric Endocriology. Ist ed. W. B. Saunders Company,1996,128.
-
2Daughaday WH,Rotwein P. Insulin-Like growth factors I and II : Peptide, mRNA and gene structure,serum and tissue concentration. Endocr Rev, 1989,10:68,.
-
3Betkers M, Oh Y, Zhang H, et al, Insulin-like growth factor II is highly selective for the type II IGF receptor in binding, crosslinking and thymidinne incorporation expriments. Endocrinology, 1991,128:1201.
-
4Lee DY, Park SK. Yorgi P, et al. Alreratio in insulin-like growth factor binding proteins (IGFBPs) ad IGFBP-3 protease activity inserum and urine from acte and chronic renal failure. J Clin Endocriol Metab, 1994,79:1376.
-
5Crargosky SE, Pham H,Wilson KF, et al. Measuremem and ctaracterization of insulin-like growth factor binding protein 3 in human biologic fluidds: descrepancies between radiommunnoassy and ligand blotting. Edoctiology, 1992,131:3051.
-
6Bang P, Erieksson U, Sara V, et al. Comparison of acid ethanol extraction and acid gel filtration prior to IGF. I and IGF- II radioimmnoassay: improvement of determinations in acid ethanol extracts by the use of a truncated IGF- I as radioligand. Acta Endocrinol, 1991,124:620.
-
7Lassare C,Hardouin S, Daffos F, et al, Serum insulin-like growth factors and their binding proteins in human fetus:relatioships with growth in normal subjects ad in subjects with intrauterine growth retardation. Pedlatr Res, 1991,29:219.
-
8Nicbolson JF. Pesoe MA, Laboratory medicine and reference tables, In: Behrman RE, Kliegmen RM, ,Arvi AM. Nelson Textbook of Pediatric, 15th ed.Philadelphia : W. B. Saunbers Company, 1996 : 2031.
-
9Haserawa Y, Hasegwa T, Fujii K,et al. High rations of free to total isuli-like growth factor-I in early infancy, J Cli Endocrinol Metab, 1997,82:156.
-
10Juul A, Skakkebaek N. Prediction of the outcome of growth homone pruvocative testing in short clildren by measurement of serom levels of insulin-like growh factor 2 and isulin-like growth factor biding protein 3.I Pediatric,1997,130:197.
-
1王昕,黄秉仁,蔡良琬,王志学.用逆转录—聚合酶链反应法对类胰岛素生长因子cDNA的扩增[J].基础医学与临床,1991,11(1):21-25.
-
2曹诣斌,吴兰亲,邵邻相,张均平,叶晓微,朱肖颖,陈学群,杜继曾.青海湖裸鲤类胰岛素生长因子IGF-Ⅱ的原核表达[J].水生生物学报,2010,34(2):459-462. 被引量:8
-
3潘爱武,叶剑,于雅杰,杨萍,林星.胰岛素样生长因子测定的临床意义[J].现代诊断与治疗,2005,16(B12):16-19. 被引量:1
-
4贾建波,李相前,朱礼尧.牛初乳胰岛素样生长因子的稳定性研究[J].食品与发酵工业,2006,32(3):26-28.
-
5项如莲,游欢庆,留佩宁,王秀娣,吴丽慧,金献江.真性性早熟治疗前后胰岛素样生长因子的观察[J].浙江临床医学,2005,7(1):25-25. 被引量:1
-
6魏辉俊,黄秉仁,蔡良琬.类胰岛素生长因子-Ⅰ的克隆、表达、分离纯化与活性检测[J].中国医学科学院学报,1997,19(5):342-345. 被引量:5
-
7徐凌,王华祖,李永泉.PKB/Akt及其生理作用的研究进展[J].国外医学(流行病学.传染病学分册),2003,30(4):233-236. 被引量:5
-
8欧阳五庆,李雅,王秋芳.生长激素和类胰岛素生长因子-1与睾丸功能[J].国外兽医学(畜禽疾病),1995,16(4):9-12.
-
9程茜.儿童生长障碍[J].中国实用儿科杂志,2015,30(12):889-892. 被引量:4
-
10李筠.生长激素缺乏症的诊断和治疗[J].现代实用医学,2004,16(9):509-510. 被引量:4