免疫球蛋白防治早产儿和足月小样儿感染(附41例临床分析)

Preventing and Treating Infection in Premature and SGA Infants by Immunoglobulin (Appendix of Clinic Analysis of 41 Cases)

目的 为了研究免疫球蛋白在防治早产儿、足月小样儿感染方面的疗效.方法 将79例早产儿及足月小样儿随机分为两组进行对比分析,其中治疗组41例(用免疫球蛋白),对照组38例(不用免疫球蛋白).结果 治疗组及对照组在感染发生率(65.85%及89.50%,P<0.05),严重感染发生率(26.80%及63.20%,P<0. 01),死亡率(9.76%及31.60%,P<0.05),出生体重≤2000g的死亡率(11.1%及66.7%,P<0.01)及孕周≤34周的死亡率(8.7%及对照组62.5%,P<0.01),差异显著或非常显著.结论 用免疫球蛋白防治早产儿及足月小样儿,能使感染率降低,死亡率明显降低,免疫球蛋白对防治早产儿及足月小样儿感染是安全而有效的.

Objective To study the effect of immunoglobulin in preventing and treating infection in premature and small for geststional age (SGA) infants. Methods 79 cases were divided and compared for analysis into two groups,41 in treatment group (treated by immunoglobu-fm)and 38 in control group. Results The incidence of infection in treatment and control group were 65. 85% and 89. 50% , P<0. 05;of severe infection were 26. 8% and 63. 2% ,P<0. 01. The rates of mortality were 9. 76% and 31. 6%, P<0. 05;of mortality in birthweight<2 000g infants were 11. 1 % and 66. 7% , P<0. 01 ;and of mortality in gestational age <34 weeks infants were 8. 7% and 62. 5% .P<0. 01. There were significant or obviously significant difference respectively. Conclusions The incidences of infection especially for the rates of mortality in premature and SGA infants were decreased by use of immunoglobulin, which was safe and effective.