期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Th17细胞与Th1、Treg细胞关系的研究进展 被引量：33

Progress in relationship between Th17 and Th1/Treg cell
下载PDF
导出
摘要 CD4^+T细胞在不同细胞因子环境中可分化为Th1、Th2、Treg、Th17四种亚群,在一定条件下,各Th细胞亚群之间可以互相转化,从而使机体的免疫效应和免疫抑制处于精细而复杂的平衡状态。Th17细胞与自身免疫性疾病和肿瘤的发生发展关系密切,研究Th17细胞与Th1细胞、Treg细胞之间的相互关系,对于预防和治疗自身免疫性疾病和肿瘤等临床难题意义重大。 In different cytokine circumstances,CD4~＋ T cell can differentiate to four subgroups,including Th1,Th2,Treg,and Th17. And the four subgroups can convert to the others in a certain condition.This ability of switch among those four subgroups makes the immunological effect and immunological suppression of body in a perfect balanced condition.Th17 cells are intimately involved in the generation and development of autoimmune disease and tumor,thus studying the relationship between Th17 and Th1 or Treg cells can promote the proceeding of preservation and therapeutics of autoimmune disease and tumor.
作者 杨丽娟 单保恩
机构地区 河北医科大学基础医学院免疫学教研室 河北医科大学第四医院科研中心
出处 《免疫学杂志》 CAS CSCD 北大核心 2010年第4期353-355,共3页 Immunological Journal
关键词 TH17细胞 TH1细胞 TREG细胞 Th17 cell Th1 cell Treg cell
分类号 R392.13 [医药卫生—免疫学]
  • 相关文献

参考文献13

  • 1Tesmer LA, Lundy SK, Ssrkar S, et al. Th17 cells in human disease[J]. Immunol Rev, 2008, 223: 87-113.
  • 2Lee YK, Turner H, Maynard CL, et al. Late developmental plasticity in the T helper 17 Lineage [J]. Immunity, 2009, 30 (1): 92-107.
  • 3Natalia MO, Yeonseok C, Seon Hee C, et al. Thl7 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Thl cells[J]. Enr J Immunol, 2009, 216 (39): 216-224.
  • 4Romagnani S. Human Th17 cells [J]. Arthritis Res Ther, 2008, 10 (2): 206.
  • 5McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road[J]. Immunity, 2008, 28 (4): 445-453.
  • 6Stummvoll GH, DiPaolo RJ, Huter EN, et al. Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells[J]. J Immunol, 2005, 181 (3): 1908-1916.
  • 7Dardalhon V, Korn T, Kuchroo VK, et al. Role of Th1 and Th17 cells in organ-specific autoimmunity[J]. J Autoimmun, 2008, 31 (3): 252-256.
  • 8Lim HW, Lee J, Hillsamer P, et al. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3 regulatory T cells [J]. J Immunol, 2008, 180 (1): 122-129.
  • 9Zhou L, Lopes JE, Chong MM, et al. TGF-beta-induced Foxp3 inhibits Thl7 cell differentiation by antagonizing RORgammat function [J]. Nature, 2008, 453 (7192): 236-240.
  • 10Miyahara Y, Odunsi K, Chen W, et al. Generation and regulation of human CD4 IL-17-producing T cells in ovarian cancer [J]. Proc Natl Acad Sci USA, 2008, 105 (40): 15505-15510.

二级参考文献18

  • 1[1]Stephens GL,Shevach EM.FaxpT regulatoiy T cells:selfishness under scrutiny[J].Inmunity,2007,27(3):417-419.
  • 2[2]Kurooka M,Kaneda Y.Inactivated Sendai virus particles eradicate tumors by inducing immune responses through blocking regulatory T cells[J].Cancer Res,2007,67(1):227-236.
  • 3[3]Liu L,Wu G,Yao JX,et al.CD4+ CD25high regulatory cells in peripheral blood of cancer patients[J].Neuro Endocrinol Lett,2008,29(2):240-245.
  • 4[4]Kono K,Kawaida H,Takahashi A,et al.CD4(+)CD25 (high)regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers[J].Cancer Immunol Immunother,2006,55(9):1064-1071.
  • 5[5]Hong J,Li N,Zhang X,et al.Induction of CD4+ CD25 + regulatory T cells by copolymer-I through activation of transcription factor Foxp3[J].Proc Natl Acad Sci US A,2005,102(18):6449-6454.
  • 6[6]Zheng SG,Wang JH,Stohl W,et al.TGF beta requires CTLA-4 early after T cell activation to induce Foxp3 and generate adaptive CD4+ CD25+ regulatory cells[J].J Immunol,2006,176(6):3321-3329.
  • 7[7]Sakaguchi S,Ono M,Setoguchi R,et al.Foxp3+ CD25 + CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease[J].Immunol Rev,2006,8:8-27.
  • 8[8]Kim JM,Rudensky A.The role of the transcription factor Foxp3 in the development of regulatory T cells[J].Immunol Rev,2006,212:86-98.
  • 9[10]Connolly JL.Changes and problematic areas in interpretation of the AJCC Cancer Staging Manual,6th Edition,for breast cancer[J].Arch Pathol Lab Med,2006,130(3):287-291.
  • 10[11]Ramsdell F,Ziegler SF.Transcription factors in autoimmunity[J].CurrOpin Immunol,2003,15(6):718-724.

共引文献8

同被引文献371

引证文献33

二级引证文献311

免疫学杂志
2010年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部