摘要
C5a由C5裂解而来,由74个氨基酸构成,是一种潜在的前炎症因子。C5a在羧肽酶的作用下迅速变成C5adesArg,通过G蛋白受体经典的通路与C5aR结合后在天然免疫中和适应性免疫中均发挥着重要的作用,非G蛋白受体通路目前的研究还不明朗。研究发现,C5a是许多自身免疫性疾病的重要病原起始物,所以抑制C5a的释放在未来的治疗中是一个很好的策略和方向。
The 74 amino acids glycoprotein,complement component 5a（C5a）,is a potent pro-inflammatory mediator cleaved enzyma tically from its precursor,C5,upon activation of the complement cascade.C5a is quickly metabolized by carboxypeptidases,forming the less potent C5adesArg.Acting via a classical G protein-coupled receptor pathway,C5a could combine with C5aR and plavs an important role both in natural immunity and adaptive immunity.While C5a＇s actions at the more recently discovered non-G protein-coupled receptor remain unclear.The study shows that C5a is the important pathogen,so making C5a inhibition an attractive therapeutic strategy.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2010年第4期362-365,共4页
Immunological Journal
