葡醛内酯联合肌苷治疗肝功能正常肝炎患者肝区疼痛的疗效分析

Glucurolactone combined with inosine could better help relieve hepatalgia for patients with chronic hep-atitis B with normal liver function

目的探讨解毒护肝药葡醛内酯(肝泰乐)联合促进能量代谢药肌苷对慢性乙型肝炎肝功能正常患者肝区疼痛的疗效。方法观察组48例患者给予肝泰乐(0.1tid)联合肌苷(0.2tid)治疗,对照组42例患者单纯给予给予肝泰乐(0.1tid),连用6周。比较两组患者的疼痛(VAS评分)和焦虑(SAS评分)缓解程度,同时比较肝功能和病毒(HBV-DNA)的变化。结果治疗后两组的以上指标均呈不同程度的下降;治疗后观察组患者的VAS及SAS评分显著低于对照组(P<0.05);治疗后观察组丙氨酸氨基转移酶(ALT)及HBV-DNA水平明显低于对照组(P<0.05)。结论解毒护肝药联合促进能量代谢药对改善疼痛的疗效优于单纯使用解毒护肝药。

Objective To evaluate the effect of glucurolactone （hepatinica of detoxification） combined with inosine （hepatinica of metabolism promoter） to treat hepatalgia patients with chronic hepatitis B with normal liver function. Methods 48 cases in the observation group were given glucurolactone 100 mg tid,combined with inosine 400 mg tid for 6 weeks. Whereas the other 42 cases in the control group were only given glucurolactone as the method of the observation ones. The level of pain and anxiety were evaluated through visual analogue scale （VAS） and self-rating anxiety scale （SAS） respectively. The liver function and hepatitis B copies were also detected. Results All the upper indexes declined after treatment and the scores of VAS and SAS in the observation were significantly lower than that of the control ones （P 0. 05）,so were the alanine aminotransferase （ALT） and HBV-DNA （P 0. 05）. Conclusion Glucurolactone combined with inosine could better help relieve hepatalgia for patients with chronic hepatitis B with normal liver function.