蛋白维护与皮肤衰老

导出

摘要氧化蛋白聚集是细胞衰老的标志，也是导致细胞出现衰老的主要原因之一。引起氧化蛋白聚集的主要原因是持续性的蛋白氧化损伤及细胞对受损氧化蛋白清除能力的下降^[1]。细胞内氧化蛋白的清除机制通常依赖于蛋白酶体系统对氧化蛋白的降解；此外，蛋白内部还有一些其他修复机制修复受损的氧化蛋白，

作者 Carine Nizard Isabelle Petropoulos Anne-Laure Buheau Marielle Moreau Sylvianne Schnebert Eric Perrier Bertrand Friguet

机构地区 LVMH Recherche Universite Paris

出处《中华皮肤科杂志》 CAS CSCD 北大核心 2010年第4期296-296,共1页 Chinese Journal of Dermatology

关键词蛋白聚集皮肤衰老氧化损伤维护细胞衰老蛋白酶体系统修复机制细胞内氧化

参考文献9

1Friguet B,Bulteau AL,Chondrogianni N,et al.Protein degradation by the proteasome and its implications in aging.Ann N Y Acad Sci,2000,908:143-154.
2Friguet B.Oxidized protein degradation and repair in ageing and oxidative stress.FEBS Lett,2006,580:2910-2916.
3Petropoulos 1,Friguet B.Maintenance of proteins and aging:The role of oxidized protein repair.Free Radic Res,2006,40:1269-1276.
4Bulteau AL,Petropoulos I,Friguet B.Age-related alterations of proteasome structure and function in aging epidermis.Exp Gerontol,2000,35:767-777.
5Bulteau AL,Moreau M,Nizard C,et al.Impairment of proteasome function upon UVA-and UVB-irradiation of human keratinocytes.Free Radic Biol Med,2002,32:1157-1170.
6Buheau AL,Morean M,Nizard C,et al.Proteasome and photoaging:the effects of UV irradiation.Ann N Y Acad Sci,2007,1100:280-290.
7Bulteau AL,Moreau M,Saunois A,et al.Algae extract-mediated stimulation and protection of proteasome activity within human keratinocytes exposed to UVA and UVB irradiation.Antioxid Redox Signal,2006,8:136-143.
8Nizard C,Friguet B,Moreau M,et al.Use of phacodactylum algae extract as cosmetic agent promoting the proteasome activity of skin cells and cosmetic composition comprising same.PCT Patent 02/080876,Assignee:LVMH Recherche(10/17/2002).
9Petropoulos I,Friguet B.Protein maintenance in aging and replicative senescence:a role for the peptide methionine sulfoxide reductases.Biochim Biophys Aeta,2005,1703:261-266.

中华皮肤科杂志

2010年第4期

内容加载中请稍等...