摘要
[目的]验证CD-147在骨肉瘤组织中的表达及与临床病理指标的相关性。[方法]SABC法免疫组化分析55例骨肉瘤组织中CD-147基因的表达,并对其与骨肉瘤临床病理的关系进行统计学分析。[结果]作者的研究提示CD-147基因在骨肉瘤组织有高表达,并且与其外科分级具有明显相关性。[结论]骨肉瘤CD-147蛋白的表达与肿瘤恶性程度密切相关,对骨肉瘤诊断和预后评估具有重要价值。
[Objective]To investigate the expressions of CD-147 in osteosarcoma samples and to research clinically pathological significance. [Methods]The expressions of CD-147 was detected by immunohistochemistry SABC method in 55 cases of osteosarcoma samples.[Results]The moderate/strong expression of CD-147 was 54.5% compared with giant cell tumor of bone.And the high expressions of CD-147 was in close correlation with diagnosis and prognosis in osteosarcoma.[Conclusion]CD-147 were overexpressed in osteosarcoma,which can be relevant to the malignant progression of osteosarcoma.
出处
《中国矫形外科杂志》
CAS
CSCD
北大核心
2010年第7期588-590,共3页
Orthopedic Journal of China
基金
辽宁省教育厅科技研究项目(2008557)
辽宁省博士启动科研基金项目(20081052)
关键词
CD-147
骨肉瘤
骨巨细胞瘤
免疫组化
CD-147
osteosarcoma
giant cell tumor of bone
immunohistochemistry
