间充质干细胞在T细胞免疫反应中的调节作用

Immune regulatory effect of masenchymal stem cells on T lymphocyte

间充质干细胞(MSCs)独特的免疫调节作用以T细胞为主,在混合淋巴细胞反应中,通过周期阻滞抑制T细胞增殖,但不引起T细胞凋亡增加、活化受抑。同时MSCs还能降低反应体系中的CD8+T细胞和Th1细胞,升高Th2细胞以抑制炎症反应,从而在T细胞介导的自身免疫性疾病中发挥治疗作用。

Mesenchymal stem cells（MSCs） have a unique role in immune regulation and focus to T-cells.In the mixed lymphocyte reactions,MSCs inhibit T-cells proliferation by cycle arrest,but they do not increase T-cell apoptosis and the suppress T-cell activation.In addition,MSCs can reduce CD8＋ T cells and Th1 cells,and simultaneously increase Th2 cells in the reaction system to suppress the inflammatory response,which may play a therapeutic effect on the T-cells mediated autoimmune diseases.