整形美容患者术前血管紧张素系统的分析

The analysis of angiotensin system in cosmetic surgery preoperative patients

目的:观察因整形美容外科手术心理应激造成患者焦虑状态时全身性血管紧张素系统中重要成分的变化情况。方法:随机选取2009年09月～2010年01在广州军区广州总医院整形外科进行外科手术的患者62例,采用STAI进行术前焦虑测评。被调查者年龄17～65岁,平均年龄(32.5±9.9)岁。并选取其中26名患者和16名正常人抽取血浆,采用酶联免疫分析法检测血液中血管紧张素系统重要成分(AngⅠ、AngⅡ和ACE)的含量,并进行统计学分析。结果:整形美容外科手术患者术前STAI值分别为:S-AI值女性:52.55±5.23,男性:53.54±7.94,和正常群体对照(女性38.97±8.45,男性39.71±8.89)有显著差异;T-AI值女性为39.57±5.65,男性40.15±6.98,与正常组(女性41.31±7.54,男性41.11±7.74)的差异不明显。对26名患者和在我院正常体检的16名正常人抽取血浆,采用酶联免疫分析法检测血液中血管紧张素系统重要成分:AngⅠ是1.67±0.31v.s0.76±0.12,AngⅡ是0.42±0.13vs0.27±0.06,ACE为0.84±0.20v.s0.41±0.10)(均P<0.01)。血管紧张素重要成分发生显著性变化。结论:整形美容外科手术的患者术前均呈现焦虑状态,血管紧张素系统可能参与手术患者心理应激所产生焦虑的调控。

Objective To investigate the state anxiety of plastic surgical preoperative patients with psychological stress and the changes of some important components of renin-angiotensin system.Methods From September 2009 to January 2010,62 patients in department of plastic surgery of Guangzhou General Hospital of Guangzhou Military Region,which were randomly selected.The anxiety state of 62 plastic and cosmetic surgical patients were tested by State-Trait Anxiety Inventory（STAI）.The age of the patients ranged from 17 to 65 years,mean age 32.5±9.9 years.Then select 26 patients in state anxiety of plastic surgical preoperation and 16 normal control persons,the levels of some important component of the blood-angiotensin system（AngⅠ,AngⅡand ACE）were detected with Enzyme-linked immunosorbent assay,and All datas was analysis by statistics.Results State Anxiety Inventory（SCI）scores were significant increased pre-operation than that of the normal control group（Female：52.55±5.23 v.s.38.97±8.45;male：53.54±7.94 v.s.39.71±8.89）.There was no significant difference of Trait Anxiety Inventory（TAI）Scores between two groups（Female：39.57±5.65 v.s.41.31±7.54;male：40.15±6.98 v.s.41.11±7.74）.The levels of AngⅠ,AngⅡand ACE were significant increased in state anxiety of plastic surgical preoperation than that of normal control group,respectively 1.67±0.31 v.s 0.76±0.12,0.42±0.13 vs 0.27±0.06,and 0.84±0.20 v.s 0.41±0.10.Conclusion Anxiety state induced by plastic and cosmetic surgical operation,angiotensin system may be involved in the regulation of state anxiety in patients undergoing psychological stress.