阴茎包埋对海绵体形态结构的影响

Concealed penis affects the morphology of the corpus cavernosum in rats

目的:探讨阴茎包埋对大鼠阴茎海绵体形态结构的影响。方法:通过建立隐匿阴茎大鼠模型获得实验标本,分2月组、4月组进行观测,每组25只大鼠。各阶段又分包埋组(15只)、正常组(10只),光镜和电镜下观察海绵体形态结构的改变。结果:阴茎包埋2月组海绵体形态结构无明显变化,4月组病理改变较为明显,光镜下见大鼠阴茎海绵体平滑肌细胞,内皮细胞分布杂乱,细胞间大量间质组织增生,海绵窦狭窄;电镜下见阴茎海绵体平滑肌细胞及内皮细胞萎缩、线粒体退变、内质网扩张,致密体及收缩纤维减少,脂滴增加,空泡形成。包埋组与正常组阴茎海绵体在外观和重量上无明显差异(P>0.05)。结论:阴茎包埋对海绵体外观和重量无明显影响,但随着包埋时间的延长,海绵体组织发生超微结构上的病理改变。

Objective：To explore the influence of concealed penis on the morphology of the corpus cavernosum in rats.Methods：Rat models of concealed penis were established by intra-pocket-suture of the root of the penis.Fifty rats were equally assigned to Groups A（2-month） and B（4-month）,each further divided into a buried（n = 15） and a normal subgroup（n = 10）.Changes in the morphology of the penile cavernous tissue were observed under the light microscope and transmission electron microscope.Results：Compared with Group A,Group B showed significant ultra-structural pathological changes in the corpus cavernosum,including abnormal arrangement of endothelial and smooth muscle cells,massive hyperplasia of interstitial tissues,narrowed cavernous sinus,atrophic smooth muscle cells,degenerated mitochondria,dilated endoplasmic reticula,decreased dense bodies and contractile fibers,and cytoplasmic vacuolization.No significant differences were found in the appearance and weight of the corpus cavernosum between the buried and normal groups（P 0.05）.Conclusion：Concealed penis does not significantly affect the appearance and weight of the corpus cavernosum,but causes ultra-structural pathological changes in it with the lengthening of time.