幽门螺杆菌感染的临床及耐药性分析

Analysis of Clinics and the Drug Resistance with Helicobacter Pylori Infection

目的了解本地区幽门螺杆菌(Hp)的药敏规律,指导临床合理用药,同时探索适合临床检验的Hp培养方法。方法对326份胃窦部活检黏膜标本用改良Skirrow培养基行微氧培养分离出120株Hp,用K-B法进行7种常用药物的敏感性检测,(甲硝唑、阿莫西林、克拉霉素、呋喃唑酮、庆大霉素、四环素及左氧氟沙星)。结果Hp对左氧氟沙星、庆大霉素、克拉霉素、阿莫西林的敏感率分别为96.67%、95.00%、91.67%、87.50%,对甲硝唑的敏感率最低,仅为51.67%。结论左氧氟沙星、庆大霉素、克拉霉素、阿莫西林等可作为根除Hp的首选药物。部分抗生素耐药率在年龄、性别方面有差异。

Objective To investigate the drug sensitivty of helicobacter pylori （Hp） and direct reasonable drug use, and then search for Hp culture methods fitted for clinical laboratory in Lu＇ an area, Anhui province. Methods 120 strains of Hp were isolated from 326 samples of gastric antrum mucosa by improved skirrow medium in microaerobic condition. 7 ordinary drugs sensitivey tests were perfromed by means of K-B, with metronidazale, amoxicilin, clarithromycin, furazolidone, gentamicin, tetracy- cline, levoflioxacin. Results The drug sensivity rates from high to low were 1evoflioxacin（96.67% ）, gentamicin （95.00%）, cla- rithromycin（91.67% ） ,amoxicilin（87.50% ） ,metronidazone is lowest（51.67% ）. Conclusion Hp infection is closely related to many kinds of gastric dieases, furazolidone, gentamicin, claritbromycin and amoxicilin are the first choice on eradication to Hp. Partof antibiotics resistance has difference to age and gender.